Note: The job is a remote job and is open to candidates in USA. Sequencing is a company focused on transforming how people understand themselves through their DNA. As a Senior Backend Engineer, you will build and improve the distributed backend systems of their genomics platform, ensuring fast, accurate, and reliable genetic guidance.
Responsibilities
- Develop and maintain high-performance and fault-tolerant distributed backend services
- Build and optimize data processing pipelines over large genomic and health datasets using Apache Spark and DuckDB
- Design data structures, storage and indexing strategies across PostgreSQL, Qdrant, and Redis for performance at scale
- Own async event processing and workflow orchestration using AWS SQS, RabbitMQ, and BullMQ
- Drive latency, throughput, and reliability through parallel execution, caching, and efficient data access
- Build guardrail and quality assurance layers that keep AI responses anchored in real genomic and scientific evidence
- Partner with bioinformatics experts to ensure outputs match the science, and with product/design specialists on user-facing behavior
Skills
- 5+ years building and operating production backend systems at scale
- Expert-level in TypeScript, comfortable owning production services end to end
- Strong distributed-systems fundamentals - you understand how they're designed and why they fail
- Hands-on with large-scale data processing frameworks (Apache Spark or equivalent) and very large datasets
- Deeply familiar with both OLTP and OLAP data systems (PostgreSQL, DuckDB)
- Solid with distributed event-driven systems
- Able to step into an unfamiliar domain like genomics, learn the mechanics fast, and go deep
- Craft-driven: you build systems properly with attention to detail and high bar for quality rather than assembling pre-made pieces
- Rust, and functional programming experience (Scala or similar)
- Python for data processing
- Experience training or fine-tuning your own AI models - not just calling APIs
- Experience with multi-agent AI systems and orchestration (planner / router / evaluator patterns)
- Production experience with LLM APIs (Anthropic, OpenAI, Bedrock, Google AI)
- Production experience with vector databases and RAG pipelines
- LLM observability tooling (Langfuse, LangSmith)
- Workflow engines (Temporal)
- Familiarity with genomics, bioinformatics, or health data systems
- High-growth startup experience
Benefits
- Comprehensive medical, dental, and vision insurance coverage
- 401(k) with company matching
- Paid time off (PTO)
- Paid volunteer time off
- Fully remote work with home office stipend
- Parental bonding leave
- Clinical-grade whole genome sequencing for you and your family (private and confidential)
Company Overview